The Phil & Penny Knight Initiative for Brain Resilience
As we age, the brain undergoes profound changes that can lead to cognitive decline and increase the risk of conditions like Alzheimer’s and epilepsy. One area of research that holds significant promise is the brain’s endocannabinoid system, often referred to as the brain’s natural “chill-out” system. This system plays a key role in regulating neural activity and preventing overstimulation. However, as we age, disruptions in this system can trigger inflammation and the production of prostaglandins, molecules linked to cognitive decline.
In our lab at Stanford, my team, in collaboration with neuroscientist Katrin Andreasson, is exploring how the endocannabinoid system could be harnessed to enhance brain resilience. Thanks to support from a Knight Initiative Catalyst Grant, we are investigating whether targeting the relationship between this system and prostaglandins can help restore cognitive function, opening the door to new therapies for age-related brain conditions
In our latest video series, we delve into our research on healthy aging and protecting against neurodegenerative diseases. We also highlight insights from Peter Klein, Ph.D., from our lab, on the potential therapeutic implications of this exciting work.
Additionally, credits for the video go to Devin Powell, and the write-up credits go to Lindsay Borthwick.