Patch-Clamp Recordings
October 13, 2020
The brain is composed of a wide array of interconnected neurons, including both excitatory principal cells and a diverse assortment of... Read More
The epileptic zebrafish model
July 2, 2020
The optical transparency and small brain sizes of larval zebrafish have enabled unprecedented access to single-cell neural dynamics across the whole... Read More
Octopus Research
April 7, 2020
Cephalopods, including the cuttlefish, octopus, and squid, possess one of the most advanced nervous systems among invertebrates. With their advanced nervous systems,... Read More
Juxtacellular Recordings
December 18, 2019
Pyramidal cells, the principal excitatory cells of the hippocampus, are under the control of a remarkably diverse set of inhibitory interneurons.  These interneurons show... Read More
Behavioral Experiments
December 18, 2019
A major impediment to progress towards reproducible, rigorous preclinical research in epilepsy is that current experimental approaches often require prohibitively time... Read More
Multi-electrode Array Recording
December 18, 2019
We use high-density silicon probes in the hippocampus and related circuits to record from single neurons and monitor the local field... Read More
Closed-Loop Optogenetics
December 18, 2019
Optogenetics is a control technology that allows the fast, selective excitation or inhibition of specific neurons with light by expressing light-sensitive... Read More
In-vivo Imaging with Miniscopes
December 18, 2019
To monitor the activity of specific cells during unrestricted behavior, we use open-source head-mounted miniscopes developed at UCLA (miniscope.org) to measure... Read More
In-vivo Calcium Imaging
December 18, 2019
We’re using 2-photon microscopy to record neuronal activity with single-cell resolution in the hippocampus of awake, behaving mice. Taking advantage of... Read More
Computational Modeling
December 18, 2019
The hippocampal circuits that store and recall spatial information are comprised of diverse cell types, each exhibiting distinct dynamics and complex... Read More