Recent Publications 2020-2024

Retrograde endocannabinoid signaling at inhibitory synapses in vivo.
Barna Dudok, Linlin Fang, Jordan S. Farrell, Shreya Malhortra, Jesslyn Homidan, Doo Kyung Kim, Celestine Wendy, Chart Ramakrishnan, Yulong Li, Karl Deisseroth, Ivan Soltesz. z
Science. 2024, Feb 29. doi.org/10.1126/science.adk3863.

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice.
Nguyen, Q. A., Klein, P. M., Xie, C., Benthall, K. N., Iafrati, J., Homidan, J., Bendor, J. T., Dudok, B., Farrell, J. S., Gschwind, T., Porter, C. L., Keravala, A., Dodson, G. S., Soltesz, I.
Nature Communications. 2024, Jan 18. doi/10.1038/s41467-024-44853-8.

Hidden behavioral fingerprints in epilepsy.
Tilo Gschwind, Ayman Zeine, Ivan Raikov, Jeffrey E. Markowitz, Winthrop F. Gillis, Sylwia Felong, Lori L. Isom, Sandeep Robert Datta, Ivan Soltesz.
Neuron. 2023, Feb 24. doi.org/10.1016/j.neuron.2023.02.003.

Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments.
Alaghband, Y., Klein, P.M., Kramár, E.A. et al. Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments.
Cell. Mol. Life Sci. 2023, Jan 6. doi.org/10.1007/s00018-022-04666-8. PMID: 36607431.

A tool for monitoring cell type-specific focused ultrasound neuromodulation and control of chronic epilepsy.
Murphy, K. R., Farrell, J. S., Gomez, J. L., Stedman, Q. G., Li, N., Leung, S. A., Good, C. H., Qiu, Z., Firouzi, K., Butts Pauly, K., Khuri-Yakub, B. P., Michaelides, M., Soltesz, I., de Lecea, L.
PNAS. 2022, Nov 7. doi: 10.1073/pnas.2206828119. PMID: 36343238.

A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations.
Liu, A. A., Henin, S., Abbaspoor, S., Bragin, A., Buffalo, E. A., Farrell, J. S., Foster, D. J., Frank, L. M., Gedankien, T., Gotman, J., Guidera, J. A., Hoffman, K. L., Jacobs, J., Kahana, M. J., Li, L., Liao, Z., Lin, J. J., Losonczy, A., Malach, R., van der Meer, M. A., McClain, K., McNaughton, B. L., Norman, Y., Navas-Olive, A., de la Prida, L. M., Rueckemann, J. W., Sakon, J. J., Skelin, I., Soltesz, I., Staresina, B. P., Weiss, S. A., Wilson, M. A., Zaghloul, K. A., Zugaro, M., Buzsaki, G.
Nature Communications. 2022, Oct 12. doi: 10.1038/s41467-022-33536-x. PMID: 36224194.

The Neurodata Without Borders ecosystem for neurophysiological data science.
Rubel, O., Tritt, A., Ly, R., Dichter, B. K., Ghosh, S., Niu, L., Baker, P., Soltesz, I., Ng, L., Svoboda, K., Frank, L., Bouchard, K. E.
eLife. 2022, Oct 4. doi: 10.7554/eLife.78362. PMID: 36193886.

Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics.
Aaron D. Milstein, Sarah Tran, Grace Ng, Ivan Soltesz.
The Journal of Physiology. 2022, July 30. doi: 10.1113/JP283216.

From single-neuron dynamics to higher-order circuit motifs in control and pathological brain networks.
Darian Hadjiabadi, Ivan Soltesz.
The Journal of Physiology. 2022, July 11. doi: 10.1113/JP282749.

Ripple-selective GABAergic projection cells in the hippocampus.
Gergely G. Szabo, Jordan S. Farrell, Barna Dudok, Wen-Hsien Hou, Anna L. Ortiz, Csab aVarga, Prannath Moolchand,
Cafer Ikbal Gulsever, Tilo Gschwind, Jordane Dimidschstein, Marco Capogna, IvanSoltesz.
Neuron. 2022, June 15. doi: 10.1016/j.neuron.2022.04.002.

Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics.
Yuanwen Jiang, Zhitao Zhang, Yi-Xuan Wang, Deling Li, Charles-Théophile Coen, Ernie Hwaun, Gan Chen, Hung-Chin Wu, Donglai Zhong, Simiao Niu, Weichen Wang, Aref Saberi, Jian-Cheng Lai, Yilei Wu, Yang Wang, Artem A. Trotsyuk, Kang Yong Loh, Chien-Chung Shih,
Wenhui Xu, Kui Liang, Kailiang Zhang, Yihong Bai, Gurupranav Gurusankar, Wenping Hu, Wang Jia, Zhen Cheng, Reinhold H. Dauskardt, Geoffrey C. Gurtner, Jeffrey B.-H. Tok, Karl Deisseroth, Ivan Soltesz, Zhenan Bao.
Science. 2022, Mar 25. doi: 10.1126/science.abj7564. Epub 2022 Mar 24.

Imaging the endocannabinoid signaling system. 
Dudok B, Soltesz I.
J Neurosci Meth. 2021, Dec 15. doi: 10.1016/j.jneumeth.2021.109451.

Toward Understanding the Diverse Roles of Perisomatic Interneurons in Epilepsy. 
Dudok B, Klein PM, Soltesz I.
Epilepsy Currents. 2021, Oct 31. doi: 10.1177/15357597211053687.

Supramammillary regulation of locomotion and hippocampal activity.
Farrell JS, Lovett-Barron M, Klein PM, Sparks FT, Gschwind T, Ortiz AL, Ahanonu B, Bradbury S, Terada S, Oijala M, Hwaun E, Dudok B,
Szabo G, Schnitzer MJ, Deisseroth K, Losonczy A, Soltesz I.
Science. 2021, Dec 16. doi: 10.1126/science.abh4272.

Bidirectional synaptic plasticity rapidly modifies hippocampal representations.
Milstein AD, Li Y, Bittner KC, Grienberger C, Soltesz I, Magee JC, Romani S.
Elife. 2021, Dec 9. doi: 10.7554/eLife.73046. PMID: 34882093.

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo.
Dong A, He K, Dudok B, Farrell JS, Guan W, Liput DJ, Puhl HL, Cai R, Wang H, Duan J, Albarran E, Ding J, Lovinger DM, Li B, Soltesz I, Li Y.
Nat Biotechnol. 2021, Nov 11. doi: 10.1038/s41587-021-01074-4.

Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.
Barna Dudok, Miklos Szoboszlay, Anirban Paul, Peter M. Klein, Zhenrui Liao, Ernie Hwaun, Gergely G. Szabo, Tristan Geiller, Bert Vancura,
Bor-Shuen Wang, Sam McKenzie, Jesslyn Homidan, Lianne M.F. Klaver, Daniel F. English, Z. Josh Huang, György Buzsáki, Attila Losonczy,
Ivan Soltesz.
Neuron. 2021, Oct 13. doi: 10.1016/j.neuron.2021.09.033.

Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function.
Peter M. Klein, Yasaman Alaghband, Ngoc-Lien Doan, Ning Ru, Olivia G. G. Drayson, Janet E. Baulch, Enikö A. Kramár, Marcelo A. Wood,
Ivan Soltesz, Charles L. Limoli.
International Journal of Molecular Sciences. 2021, Aug 21. doi: 10.3390/ijms22169020.

In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity.
Jordan S Farrell, Roberto Colangeli, Ao Dong, Antis G George, Kwaku Addo-Osafo, Philip J Kingsley, Maria Morena, Marshal D Wolff, Barna Dudok, Kaikai He, Toni A Patrick, Keith A Sharkey, Sachin Patel, Lawrence J Marnett, Matthew N Hill, Yulong Li, G Campbell Teskey,
Ivan Soltesz.
Neuron. 2021, Aug 4. doi: 10.1016/j.neuron.2021.05.026.

Maximally selective single-cell targetfor circuit control in epilepsy models.
Darian Hadjiabadi, Matthew Lovett-Barron, Ivan Georgiev Raikov, Fraser T. Sparks, Zhenrui Liao, Scott C. Baraban, Jure Leskovec, Attila Losonczy, Karl Deisseroth, Ivan Soltesz.
Neuron. 2021, Jun 30. doi: 10.1016/j.neuron.2021.06.007.

Epistemic Autonomy: Self-supervised Learning in the Mammalian Hippocampus.
Santos-Pata, D., Amil, A.F., Raikov, I.G., Rennó-Costa, C., Mura, A., Soltesz, I., Verschure, P.F.M.J.
Trends in Cognitive Science, 2021 Apr 24. doi: 10.1016/j.tics.2021.03.016.

Entorhinal mismatch: A model of self-supervised learning in the hippocampus.
Santos-Pata, D., Amil, A.F., Raikov, I.G., Rennó-Costa, C., Mura, A., Soltesz, I., Verschure, P.F.M.J.
iScience 2021, March 26. doi: 10.1016/j.isci.2021.102364.

Alternating sources of perisomatic inhibition during behavior.
Barna Dudok, Peter M. Klein, Ernie Hwaun, Brian R. Lee, Zizhen Yao, Olivia Fong, John C. Bowler, Satoshi Terada, Fraser T. Sparks, Gergely G. Szabo, Jordan S. Farrell, Jim Berg, Tanya L. Daigle, Bosiljka Tasic, Jordane Dimidschstein, Gord Fishell, Attila Losonczy, Hongkui Zeng,
Ivan Soltesz.
Neuron, 2021 Feb 1. doi: 10.1016/j.neuron.2021.01.003.

Detrimental impacts of mixed-ion radiation on nervous system function.
Klein PM, Parihar VK, Szabo GG, Zöldi M, Angulo MC, Allen BD, Amin AN, Nguyen QA, Katona I, Baulch JE, Limoli CL, Soltesz I.
Neurobiol Dis. 2021 Apr. doi: 10.1016/j.nbd.2021.105252. Epub 2021 Jan 5.

Transcriptional readout of neuronal activity via an engineered Ca2+-activated protease.
Mateo I. Sanchez, Quynh-Anh Nguyen, Wenjing Wanga, Ivan Soltesz, Alice Y. Ting.
PNAS. 2020 Dec 29. doi: 10.1073/pnas.2006521117.

Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy.
Sparks FT, Liao Z, Li W, Grosmark A, Soltesz I, Losonczy A.
Nat Commun. 2020 Dec 1. doi: 10.1038/s41467-020-19969-2.

Deep brain optogenetics without intracranial surgery.
Chen R, Gore F, Nguyen QA, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K.
Nat Biotechnol. 2020 Oct 5. doi: 10.1038/s41587-020-0679-9. PMID: 33020604.

GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep.
Billwiller F, Castillo L, Elseedy H, Ivanov AI, Scapula J, Ghestem A, Carponcy J, Libourel PA, Bras H, Abdelmeguid NE, Krook-Magnuson E, Soltesz I, Bernard C, Luppi PH, Esclapez M.
Brain Struct Funct. 2020 Sept 24. doi: 10.1007/s00429-020-02146-y. PMID: 32970253.

In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia.
Farrell JS, Colangeli R, Dudok B, Wolff MD, Nguyen SL, Jackson J, Dickson CT, Soltesz I, Teskey GC.
Sci Rep. 2020 Sep 14. doi: 10.1038/s41598-020-71935-6. PMID: 32929133.

Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures.
Nguyen QA, Moolchand P, Soltesz I.
Trends Neurosci. 2020 Aug. doi: 10.1016/j.tins.2020.04.006. PMID: 32376035.

Mitigation of helium irradiation-induced brain injury by microglia depletion.
Allen BD, Syage AR, Maroso M, Baddour AAD, Luong V, Minasyan H, Giedzinski E, West BL, Soltesz I, Limoli CL, Baulch JE, Acharya MM.
J Neuroinflammation. 2020 May 19. doi: 10.1186/s12974-020-01790-9. PMID: 32429943.

Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy.
Dey D, Parihar VK, Szabo GG, Klein PM, Tran J, Moayyad J, Ahmed F, Nguyen QA, Murry A, Merriott D, Nguyen B, Goldman J, Angulo MC, Piomelli D, Soltesz I, Baulch JE, Limoli CL.
Radiat Res. 2020 March. doi: 10.1667/RR15540.1. PMID: 32134362.

Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy.
Kim HK, Gschwind T, Nguyen TM, Bui AD, Felong S, Ampig K, Suh D, Ciernia AV, Wood MA, Soltesz I.
Epilepsia. 2020 Mar. doi: 10.1111/epi.16445. PubMed PMID: 32072628; NIHMSID: NIHMS1552790.

Selected publications 2015-2019

Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study.
Rennó-Costa C, Teixeira DG, Soltesz I.
Hippocampus. 2019 Oct. doi: 10.1002/hipo.23093. PMID: 30990954.

Plants come to mind: phytocannabinoids, endocannabinoids and the control of seizures.
Farrell JS, Soltesz I.
Addiction. 2019 Aug. doi: 10.1111/add.14540. PubMed PMID: 30589476.

New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation.
Acharya MM, Baulch JE, Klein PM, Baddour AAD, Apodaca LA, Kramár EA, Alikhani L, Garcia C Jr, Angulo MC, Batra RS, Fallgren CM, Borak TB, Stark CEL, Wood MA, Britten RA, Soltesz I, Limoli CL.
eNeuro. 2019 Aug 22. doi: 10.1523/ENEURO.0094-19.2019. PMID: 31383727.

Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks.
Farrell JS, Nguyen QA, Soltesz I.
Neuron. 2019 Mar 20. doi: 10.1016/j.neuron.2019.01.043. Review. PubMed PMID: 30897354.

Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice.
Marchionni I, Oberoi M, Soltesz I, Alexander A.
Epilepsia Open. 2019 Jun. doi:10.1002/epi4.12310. PubMed PMID: 31168492.

CA1 pyramidal cell diversity enabling parallel information processing in the hippocampus.
Soltesz I, Losonczy A.
Nat Neurosci. 2018, Apr 21. doi: 10.1038/s41593-018-0118-0. Epub 2018 Mar 28. Review. PubMed PMID: 29593317; PubMed Central PMCID: PMC5909691.

Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory.
Bui AD, Nguyen TM, Limouse C, Kim HK, Szabo GG, Felong S, Maroso M, Soltesz I.
Science. 2018, Feb 16. doi: 10.1126/science.aan4074. PubMed PMID: 29449490; PubMed Central PMCID: PMC6040648.

Single Bursts of Individual Granule Cells Functionally Rearrange Feedforward Inhibition. z
Neubrandt M, Oláh VJ, Brunner J, Marosi EL, Soltesz I, Szabadics J.
J Neurosci. 2018, Feb 14. doi: 10.1523/JNEUROSCI.1595-17.2018. Epub 2018 Jan 15. PubMed PMID: 29335356; PubMed Central PMCID: PMC5815453.

Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy.
Neumann AR, Raedt R, Steenland HW, Sprengers M, Bzymek K, Navratilova Z, Mesina L, Xie J, Lapointe V, Kloosterman F, Vonck K, Boon PAJM, Soltesz I, McNaughton BL, Luczak A.
Brain. 2017, Sep 1. doi: 10.1093/brain/awx179. PubMed PMID: 29050390; PubMed Central PMCID: PMC6248724.

Hippocampal Dentate Mossy Cells Improve Their CV and Trk into the Limelight.
Milstein AD, Soltesz I.
Neuron. 2017, Aug 16. doi: 10.1016/j.neuron.2017.08.005. PMID: 28817795.

Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.
Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I.
Elife. 2016 Dec 23. doi: 10.7554/eLife.18566. PubMed PMID: 28009257; PubMed Central PMCID: PMC5313080.

Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission.
Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I.
Brain Struct Funct. 2017 Jul;222(5):2345-2357. doi: 10.1007/s00429-016-1345-3. Epub 2016 Nov 30. PMID: 27905022; PMCID: PMC5504243.

Cannabinoid Control of Learning and Memory through HCN Channels.
Maroso M, Szabo GG, Kim HK, Alexander A, Bui AD, Lee SH, Lutz B, Soltesz I.
Neuron. 2016 Mar 2;89(5):1059-73. doi: 10.1016/j.neuron.2016.01.023. Epub 2016 Feb 18. PMID: 26898775; PMCID: PMC4777634.

Hippogate: a break-in from entorhinal cortex.
Alexander A, Soltesz I.
Nat Neurosci. 2016 Apr;19(4):530-2. doi: 10.1038/nn.4253. Epub 2016 Feb 15. PMID: 26878673.

Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.
Bui AD, Alexander A, Soltesz I.
Neuroscientist. 2017 Feb;23(1):68-81. doi: 10.1177/1073858415619600. Epub 2016 Jul 9. PMID: 26700888; PMCID: PMC4919242.

Brain State Is a Major Factor in Preseizure Hippocampal Network Activity and Influences Success of Seizure Intervention.
Ewell LA, Liang L, Armstrong C, Soltész I, Leutgeb S, Leutgeb JK.
J Neurosci. 2015 Nov 25;35(47):15635-48. doi: 10.1523/JNEUROSCI.5112-14.2015. PMID: 26609157; PMCID: PMC4659826.

Pass-Through Code of Synaptic Integration.
Szabo GG, Soltesz I.
Neuron. 2015 Sep 23;87(6):1124-1126. doi:10.1016/j.neuron.2015.09.006. PMID: 26402596.

Neuroelectronics and Biooptics: Closed-Loop Technologies in Neurological Disorders.
Krook-Magnuson E, Gelinas JN, Soltesz I, Buzsáki G.
JAMA Neurol. 2015 Jul;72(7):823-9. doi: 10.1001/jamaneurol.2015.0608. PMID: 25961887; PMCID: PMC4501886.

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.
Soltesz I, Alger BE, Kano M, Lee SH, Lovinger DM, Ohno-Shosaku T, Watanabe M.
Nat Rev Neurosci. 2015 May;16(5):264-77. doi: 10.1038/nrn3937. Erratum in: Nat Rev Neurosci. 2015 Jun;16(6):372. PMID: 25891509.

Beyond the hammer and the scalpel: selective circuit control for the epilepsies.
Krook-Magnuson E, Soltesz I. Nat Neurosci. 2015 Mar;18(3):331-8. doi: 10.1038/nn.3943.
Epub 2015 Feb 24. PMID: 25710834; PMCID: PMC4340083.

Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling.
Dudok B, Barna L, Ledri M, Szabó SI, Szabadits E, Pintér B, Woodhams SG, Henstridge CM, Balla GY, Nyilas R, Varga C, Lee SH, Matolcsi M, Cervenak J, Kacskovics I, Watanabe M, Sagheddu C, Melis M, Pistis M, Soltesz I, Katona I.
Nat Neurosci. 2015 Jan;18(1):75-86. doi: 10.1038/nn.3892. Epub 2014 Dec 8. PMID: 25485758; PMCID: PMC4281300.